When the Need is Fast and Effective Control in your Arrhythmia Patients
Available in Oral and Injectable Formulation
Mexohar Capsules of 50 mg and 150 mg
Class 1B Antiarrhythmic
MEXOHAR® (mexiletine hydrochloride) is an orally active antiarrhythmic agent available as 50 mg and 150 mg capsules and 250 mg injection. 100 mg of mexiletine hydrochloride is equivalent to 83.31 mg of mexiletine base. It is a white to off-white crystalline powder with slightly bitter taste, freely soluble in water and in alcohol. MEXOHAR has a pKa of 9.2.
Mechanism of Action
MEXOHAR (mexiletine hydrochloride) is a local anesthetic, antiarrhythmic agent, structurally similar to lidocaine, but orally active. In animal studies, MEXOHAR has been shown to be effective in the suppression of induced ventricular arrhythmias, including those induced by glycoside toxicity and coronary artery ligation. MEXOHAR, like lidocaine, inhibits the inward sodium current, thus reducing the rate of rise of the action potential, Phase 0. MEXOHAR decreased the effective refractory period (ERP) in Purkinje fibers. The decrease in ERP was of lesser magnitude than the decrease in action potential duration (APD), with a resulting increase in the ERP/APD ratio.